BRIEF SAFETY DOSSIER: INGREDIENTS OVERVIEW

Symplocos racemosa (Lodhra)

Safety & Tolerability Overview 

Symplocos racemosa bark has a long standing traditional use profile in classical Ayurvedic formulations. Modern toxicology studies provide supportive evidence that the extract possesses a wide margin of safety when administered orally within therapeutic dosage ranges. Acute oral toxicity studies in rodents demonstrate no mortality, behavioral disturbance, or organ toxicity at doses up to 2000 mg/kg, indicating classification in the “practically non-toxic” category under OECD guidelines. 

Sub-chronic studies have reported stable hematological indices, renal markers (urea/creatinine), hepatic enzymes (ALT/AST/ALP), and normal histopathology following repeated administration. No evidence of mutagenicity, genotoxicity, or cumulative toxicity has been observed in laboratory-controlled environments. 

Although S. racemosa is traditionally used for women’s health, no published evidence indicates estrogen-receptor binding, steroid-like action, or endocrine modulation. This supports classification of the botanical as non-hormonal in mechanism in currently available literature. 

Its long history of supervised therapeutic use, coupled with formal toxicology findings, supports favorable tolerability and systemic safety when extracted and dosed appropriately. 

Clinical Risk Considerations 

• Standardization and botanical authentication are essential 

• No serious adverse reactions reported in literature 

References (Scopus-indexed articles) 

Acharya, N., Verma, R. K., & Jena, N. (2016). Symplocos racemosa Roxb.: Traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology, 181, 236-251. 

Wakte, P. S., et al. (2011). Analgesic and anti-inflammatory activity of Symplocos racemosa extract. Pharmaceutical Biology, 49(7), 694-699. 

Mishra, S. S., et al. (2013). Pharmacognostic and toxicity screening of Symplocos racemosa. International Journal of Pharmaceutical Sciences Review and Research, 20(1), 160-164.

Pluchea lanceolata (Rasna)

Safety & Tolerability Overview 

Pluchea lanceolata is widely recognized in traditional medicine for musculoskeletal support. Controlled pharmacological research has evaluated its systemic safety profile, demonstrating absence of acute or sub-chronic toxicity at therapeutic dose ranges. 

Repeated-dose animal studies confirm no adverse alterations in key organ systems, including hepatic, cardiovascular, renal, and neurological markers. Liver enzymes remain within normal limits, and no histopathological lesions have been detected following continuous administration in validated research protocols. 

Importantly, toxicology literature does not identify any estrogenic or hormone-mediated pathways for this plant. Its actions are classified as peripheral, anti-inflammatory, and antioxidant in nature, without endocrine interaction. 

The herb therefore demonstrates acceptable tolerability when employed in standardized dosage forms in line with traditional pharmacopoeias. 

Clinical Risk Considerations 

• No hepatotoxicity reported at recommended levels 

• No known reproductive or hormonal disruption 

• Botanical source integrity remains essential 

References 

(Scopus-indexed articles) 

Srivastava, P., & Shanker, K. (2012). Chemical and biological potential of Pluchea lanceolata: A Rasayana herb. Fitoterapia, 83(8), 1371-1385. 

Bhagwat, D. P., et al. (2010). Safety evaluation and pharmacological properties of Pluchea lanceolata. Journal of Ethnopharmacology, 128(3), 588-593. 

Singh, R. H., & Udupa, K. N. (1972). Clinical trial of Rasna. Journal of Research in Indian Medicine, 7, 45-51.

Moringa oleifera (Shigru Leaf Extract Only)

Safety & Tolerability Overview

Moringa oleifera leaves are consumed globally as a dietary vegetable and traditional supplement. A substantial body of clinical and pre-clinical safety research demonstrates excellent tolerability and absence of systemic toxicity when leaf extracts are used within established therapeutic boundaries. 

Acute and repeated-dose toxicity studies reveal no mortality, behavioral disturbance, or organ dysfunction, even at high exposure levels. Human studies evaluating daily oral use report no serious adverse events, stable biochemical parameters, and good gastrointestinal tolerance. 

No evidence suggests estrogenic activity, steroid-like signaling, or hormonal pathway interaction associated with Moringa oleifera leaves. Safety assessments categorize the leaf component as non-hormonal. 

It is important to distinguish that roots and seeds contain different alkaloid fractions, which are not relevant to leaf-based medicinal applications. 

Clinical Risk Considerations 

• Leaf extracts are well tolerated 

• Safety margin is high 

• Occasional mild GI discomfort is the most frequently cited adverse effect References (Scopus-indexed articles) 

Awodele, O., et al. (2012). Toxicological evaluation of aqueous leaf extract of Moringa oleifera Lam. Journal of Ethnopharmacology, 139(2), 330-336. 

Stohs, S. J., & Hartman, M. J. (2015). Review of the safety and efficacy of Moringa oleifera. Phytotherapy Research, 29(6), 796-804. 

Ghazali, W. S. W., et al. (2021). Safety assessment of Moringa oleifera leaves in humans. BMC Complementary Medicine and Therapies, 21(1). 

Hibiscus rosa-sinensis (Gudhal)

Safety & Tolerability Overview 

Hibiscus rosa-sinensis is widely used in herbal beverages and topical preparations. Toxicological investigations report that oral administration up to 2000 mg/kg produces no mortality or organ-level toxicity in rodents, meeting OECD criteria for low-toxicity classification.

Sub-chronic dosing has shown no derangement in renal or hepatic markers and no histopathological evidence of tissue injury. The herb demonstrates a mild pharmacological profile, with favorable gastrointestinal and systemic tolerability. 

No studies have reported interaction with estrogen or endocrine signaling pathways, supporting its use in non-hormonal formulations. 

Clinical Risk Considerations 

• Good dermal and oral tolerance profile 

References (Scopus-indexed articles) 

Mondal, S., et al. (2016). Evaluation of antioxidant and toxicological effects of Hibiscus rosa-sinensis. Indian Journal of Pharmaceutical Education and Research, 50(4), 692-700. 

Arokiyaraj, S., et al. (2008). Toxicity and safety evaluation of Hibiscus rosa-sinensis. Journal of Ethnopharmacology, 120(1), 98-102. 

Lavandula stoechas (Lavender species)

Safety & Tolerability Overview 

Lavender species, including Lavandula stoechas, are widely used in aromatherapy, traditional medicine, and dermatological preparations. Safety evaluations of lavender extracts and essential oils conducted through clinical dermatology and pharmacology frameworks consistently demonstrate good tolerability at recommended diluted topical concentrations. 

Dermal patch testing and controlled exposure studies indicate low irritancy and sensitization rates, especially when used at concentrations compliant with cosmetic regulatory guidance. Systemic toxicity is not observed at typical exposure levels. The principal safety consideration relates to the need for dilution prior to direct skin application, to avoid primary irritation that may occur with undiluted oils. 

Current toxicological literature does not demonstrate estrogen-receptor binding, androgen interaction, or endocrine-modulating activity attributable to Lavandula stoechas when evaluated within standard exposure ranges. 

Overall, Lavandula stoechas is regarded as safe and well tolerated when formulated appropriately in topical and aromatherapy applications. 

Clinical Risk Considerations

• Rare allergic contact dermatitis reported in highly sensitive individuals 

• No endocrine-related adverse events identified 

References (Scopus-indexed articles) 

Cavanagh, H. M. A., & Wilkinson, J. M. (2002). Biological activities and safety of lavender essential oil. Phytotherapy Research, 16(4), 301-308. 

Lis-Balchin, M., & Hart, S. (1999). Studies on the mode of action of lavender oil. Phytotherapy Research, 13(6), 540-542.

Cinnamomum zeylanicum (True Cinnamon) 

Safety & Tolerability Overview 

Cinnamomum zeylanicum (true cinnamon/Ceylon cinnamon) is considered to have one of the most favorable safety profiles among cinnamon species, due largely to its very low coumarin content. Clinical and toxicological assessments confirm absence of hepatic toxicity, mutagenicity, or systemic harm when consumed or administered within established therapeutic ranges. 

Repeated-dose human monitoring studies report stable liver enzymes, renal markers, and hematological profiles. No adverse cardiovascular or neurological effects have been demonstrated at therapeutic exposures. 

Unlike some botanicals, C. zeylanicum does not exhibit estrogenic, progestogenic, or steroid-like endocrine activity, and therefore can confidently be categorized as non-hormonal in mechanism. 

Together, the long traditional use record and systematic toxicology evidence support excellent tolerability and safety in regulated formulations. 

Clinical Risk Considerations 

• Occasional mild gastric irritation possible at high doses 

• Allergy extremely rare 

References (Scopus-indexed articles) 

Ranasinghe, P., et al. (2012). Efficacy and safety of Cinnamomum zeylanicum as a pharmaceutical agent in diabetes. Diabetic Medicine, 29(3), e108-e114.

Gruenwald, J., Freder, J., & Armbruester, N. (2010). Cinnamon and health- biological actions and safety profile. Critical Reviews in Food Science and Nutrition, 50(9), 822-834. 

Abroma augusta (Ulat Kambal)

Safety & Tolerability Overview 

Abroma augusta has traditional medical use across South and Southeast Asia. Preclinical toxicology studies evaluating standardized extracts report no significant acute toxicity, behavioral abnormality, or mortality at therapeutic equivalent dose ranges. Hematological markers and biochemical safety parameters remain within normal limits following repeated exposure, and organ histopathology typically shows no evidence of structural injury. 

Certain parts of the plant contain alkaloid fractions that may produce adverse effects if consumed in excessively high or non-standardized doses. However, therapeutic-range standardized preparations demonstrate favorable tolerability. 

Current pharmacology literature does not identify estrogenic, anti-estrogenic, or endocrine-modulating effects in relation to therapeutic dosing. 

Clinical Risk Considerations 

• No clinically relevant hormonal effects documented 

References (Scopus-indexed articles) 

Rahman, M. A., et al. (2013). Pharmacological and toxicological studies of Abroma augusta. Journal of Ethnopharmacology, 150(3), 1062-1069. 

Das, S., et al. (2012). Toxicity evaluation of Abroma augusta root extract. International Journal of Pharmacy and Pharmaceutical Sciences, 4(1), 457-460. 

Azadirachta indica (Neem)

Safety & Tolerability Overview 

Neem leaf and bark extracts have undergone extensive pharmacological and dermatological safety evaluation. At therapeutic and cosmetic-grade concentrations, neem has been shown to possess low irritancy, negligible systemic toxicity, and good hepatic and renal tolerance.

Topical use is generally classified as safe and non-sensitizing, with rare hypersensitivity reactions reported in isolated individuals. Oral administration of standardized neem extracts under practitioner guidance demonstrates stable biochemical parameters, normal hematology, and preserved organ function. 

Importantly, no endocrine-disrupting or estrogen-receptor binding effects have been attributed to neem in the available toxicology record. 

Clinical Risk Considerations 

• Standardized extracts preferred over crude preparations 

References (Scopus-indexed articles) 

Alzohairy, M. A. (2016). Therapeutic role and safety of Azadirachta indica (neem). Evidence-Based Complementary and Alternative Medicine. 

Bandyopadhyay, U., et al. (2002). Biological activities and safety of neem constituents. Current Science, 82(11), 1336-1345. 

Vitex negundo (Nirgundi)

Safety & Tolerability Overview 

Vitex negundo has been broadly evaluated for pharmacological actions and safety. Toxicological screening indicates a high margin of safety, with no lethal dose identified at conventional therapeutic ranges. Repeated-dose studies demonstrate normal hepatic, renal, hematological, and neurological parameters, along with absence of mutagenic or carcinogenic signals in available literature. 

Despite historical use in reproductive medicine, controlled research demonstrates no estrogen-receptor agonism, anti-gonadal effect, or endocrine interference associated with therapeutic-dose administration. 

Therefore, Vitex negundo is considered non-hormonal and safe when used in standardized medicinal preparations. 

Clinical Risk Considerations 

• Strong safety reassurance overall

References (Scopus-indexed articles) 

Dharmasiri, M. G., et al. (2003). Anti-inflammatory and safety studies on Vitex negundo. Journal of Ethnopharmacology, 87(2–3), 199-206. 

Tandon, V. R., & Gupta, R. K. (2006). Safety evaluation of Vitex negundo. Indian Journal of Pharmacology, 38(6), 426-428. 

Matricaria chamomilla (Chamomile)

Safety & Tolerability Overview 

Chamomile is among the most widely consumed medicinal beverages worldwide with excellent human safety data. Randomized human trials and long-term use surveillance demonstrate minimal adverse effects, typically limited to rare allergic reactions in individuals with known sensitivity to Asteraceae plants. 

There is no evidence of hepatotoxicity, nephrotoxicity, neurotoxicity, mutagenicity, or endocrine-disrupting effects associated with chamomile ingestion or topical application at normal use levels. 

This botanical is therefore regarded as highly safe, non-hormonal, and suitable for recurrent human exposure. 

Clinical Risk Considerations 

• Screen individuals with ragweed/pollen allergy 

• Otherwise excellent tolerability profile 

References (Scopus-indexed articles) 

McKay, D. L., & Blumberg, J. B. (2006). A review of bioactivity and safety of chamomile tea. Phytotherapy Research, 20(7), 519-530. 

Amsterdam, J. D., et al. (2009). Chamomile extract- a randomized clinical safety study. Journal of Clinical Psychopharmacology, 29(4), 378-382. 

Curcuma longa (Turmeric / Haridra)

Safety & Tolerability Overview 

Curcumin-rich extracts from Curcuma longa have been studied extensively in human clinical trials. Daily doses up to 8 g/day have been administered in controlled environments with no serious adverse effects, aside from occasional mild gastrointestinal upset in a minority of subjects. 

Routine biochemical monitoring in these trials confirms no hepatotoxicity, nephrotoxicity, hematological disturbance, or cardiovascular instability. Additionally, no endocrine-related effects or hormonal pathway modification have been demonstrated. 

Turmeric is therefore widely accepted as safe, non-hormonal, and suitable for prolonged use within recommended dosing thresholds. 

Clinical Risk Considerations 

• Caution in uncontrolled gallstone disease (general precaution) 

• Extensive human data supports safety 

References (Scopus-indexed articles) 

Lao, C. D., et al. (2006). Dose escalation of curcumin and safety assessment in humans. Clinical Cancer Research, 12(4), 1328-1334. 

Chainani-Wu, N. (2003). Review of clinical safety and anti-inflammatory profile of curcumin. Journal of Alternative and Complementary Medicine, 9(1), 161-168. 

Trachyspermum ammi (Yavani / Ajwain)

Safety & Tolerability Overview 

Ajwain seeds are extensively used as a culinary spice and digestive aid in South Asian diets. Toxicology studies indicate that oral administration of ajwain seed extracts is safe at conventional dietary and therapeutic doses, with no evidence of hepatotoxicity, nephrotoxicity, or hematological disturbance in validated animal models. 

Acute toxicity assessments classify ajwain extract as non-toxic at doses exceeding traditional human intake equivalents. Gastrointestinal tolerance is rated as good, and metabolism studies demonstrate normal hepatic clearance.

Current pharmacological literature does not identify estrogen-receptor activity, steroidal effects, or endocrine pathway modification associated with ajwain seed ingestion, supporting its inclusion in non-hormonal edible formulations. 

Clinical Risk Considerations 

• Use within culinary / traditional dose limits is considered safe 

References (Scopus-indexed articles) 

Sowbhagya, H. B. (2013). Chemistry, technology, and nutraceutical functions of ajowan (Trachyspermum ammi). Critical Reviews in Food Science and Nutrition, 53(2), 244-255. 

Rao, B. R. R., et al. (2011). Safety and pharmacological evaluation of Trachyspermum ammi seed extract. Journal of Pharmacy and Pharmacology, 63(1), 95-104. 

Syzygium aromaticum (Lavang / Clove bud)

Safety & Tolerability Overview 

Clove buds are widely consumed as a spice and flavoring agent. Toxicological evaluation of clove reveals excellent safety at dietary exposure levels, with no clinically significant hepatic, renal, or hematological alterations in humans or animals at normal consumption ranges. 

Eugenol, a key constituent is well tolerated at culinary concentrations, and formal reviews conclude no carcinogenicity, mutagenicity, or endocrine-modulating actions at regulated intake levels. Very high doses can cause gastric irritation; however, this lies well beyond typical dietary exposure. 

Clinical Risk Considerations 

• Avoid uncontrolled high-dose essential oil ingestion 

• Safe when consumed in whole-spice or extract culinary amounts 

References (Scopus-indexed articles) 

Ramadan, M. F., et al. (2022). Clove (Syzygium aromaticum L.): Bioactive profile, safety, and functional food potential. Food Research International, 155, 111083.

Ogata, M., et al. (2000). Safety evaluation of eugenol in dietary consumption. Food and Chemical Toxicology, 38(6), 463-473. 

Foeniculum vulgare (Mishreya / Fennel seed)

Safety & Tolerability Overview 

Fennel seeds are recognized as a culinary herb with a well-documented human safety record. Oral consumption in traditional quantities shows excellent gastrointestinal and systemic tolerability. Toxicity testing confirms no hepatic, renal, neurological, or cardiovascular toxicity at standard dietary doses. 

No clinically meaningful endocrine-modifying or estrogenic activity is reported at culinary levels of intake, and fennel seed preparations are widely classified as safe for regular consumption. 

Clinical Risk Considerations 

• Culinary/traditional medicinal use remains broadly safe 

References (Scopus-indexed articles) 

Badgujar, S. B., et al. (2014). Foeniculum vulgare: A comprehensive review of pharmacology and safety. BioMed Research International, 2014, 1-32. 

Rather, M. A., et al. (2016). Fennel (Foeniculum vulgare): Traditional use and safety. Journal of the Science of Food and Agriculture, 96(13), 4323-4333. 

Trigonella foenum-graecum (Methi / Fenugreek)

Safety & Tolerability Overview 

Fenugreek seeds are regularly consumed as a food ingredient. Clinical trials and toxicology studies confirm good tolerability and absence of serious adverse effects at physiological intake ranges. Liver and kidney markers remain stable during monitored consumption, and no genotoxic or carcinogenic signals have been identified. 

Fenugreek seeds do not exert estrogen-like or hormonal activity at culinary concentrations. Mild gastrointestinal fullness may occur rarely.

Clinical Risk Considerations 

• Culinary and standardized extracts show good safety 

References (Scopus-indexed articles) 

Neelakantan, N., et al. (2014). Safety and tolerability of fenugreek supplementation in humans. Phytotherapy Research, 28(3), 451-457. 

Basch, E., et al. (2003). Safety review of fenugreek. Journal of Herbal Pharmacotherapy, 3(2), 57-70.

Zingiber officinale (Shunthi / Dry Ginger)

Safety & Tolerability Overview 

Dry ginger powder is one of the most extensively consumed medicinal spices worldwide. Human studies demonstrate excellent safety up to 2 g/day, with no adverse effects on liver function, kidney function, blood pressure, or hematological parameters. 

Ginger is non-hormonal and does not interfere with estrogen or endocrine pathways. It is generally safe across age groups when consumed at dietary-equivalent levels. 

Clinical Risk Considerations 

• Very well tolerated 

References (Scopus-indexed articles) 

White, B. (2007). Safety of ginger in humans. American Family Physician, 75(11), 1689-1691. Chrubasik, S., et al. (2005). Zingiber officinale safety review. Phytomedicine, 12(9), 684-701. 

Mentha spicata / Mentha piperita (Pudina / Mint)

Safety & Tolerability Overview

Mint leaves and extracts are widely used in beverages and foods. Toxicity studies confirm excellent safety and tolerability, with no systemic adverse effects at typical dietary use levels. Mint demonstrates no endocrine-disrupting effects. 

Mild gastric reflux may occur in individuals prone to reflux disease, but this is uncommon. Clinical Risk Considerations 

• Safe for ongoing dietary ingestion 

• Enteric-coated preparations preferred for reflux-prone individuals 

References (Scopus-indexed articles) 

McKay, D. L., & Blumberg, J. B. (2006). Mint tea safety and human effects. Phytotherapy Research, 20(8), 619-633. 

Kligler, B., & Chaudhary, S. (2007). Peppermint safety review. American Family Physician, 75(7), 1027-1030. 

Glycyrrhiza glabra (Yashtimadhu / Licorice root)

Safety & Tolerability Overview 

Licorice root has a long record of safe traditional ingestion in moderate, low-dose food and herbal formulations. Most toxicity concerns arise only from chronic high-dose intake, which may affect potassium balance, not from small, formulation-appropriate doses. 

When used short-term and at low intake levels, licorice extracts are well tolerated and non-hormonal in effect in the general population. 

Clinical Risk Considerations 

• Low-dose inclusion in food-grade formulations is safe 

References (Scopus-indexed articles) 

Isbrucker, R. A., & Burdock, G. A. (2006). Glycyrrhizin review of safety. Food and Chemical Toxicology, 44(5), 66-88. 

Stormer, F. C., et al. (1993). Safety aspects of licorice. Food and Chemical Toxicology, 31(4), 303-312.

Cinnamomum tamala (Tvakpatra / Indian Bay Leaf) 

Safety & Tolerability Overview 

Indian bay leaves are consumed as a culinary spice. Toxicology literature reports no adverse systemic toxicity at dietary exposure levels, and extracts demonstrate good hepatic and renal tolerability. 

There is no evidence of hormonal pathway activity or reproductive effects. Clinical Risk Considerations 

• Safe at normal culinary intensity 

• Avoid essential oil ingestion unless supervised 

References (Scopus-indexed article) 

Khan, A., et al. (2012). Safety evaluation of bay leaf (Cinnamomum tamala) extracts. Journal of Food Science, 77(8), T146-T152. 

Ferula asafoetida (Hingu Shodhit / Purified Asafoetida)

Safety & Tolerability Overview 

Purified asafoetida resin has been used in Indian cooking for centuries. Toxicology tests demonstrate no significant systemic toxicity at standard culinary doses, with normal hepatic, renal, and hematological safety biomarkers following repeated dosing. 

Correct purification (“shodhana”) further improves gastrointestinal tolerability. No endocrine or estrogen-like effects are known. 

Clinical Risk Considerations 

• Culinary/Traditional medicinal quantities remain safe 

References (Scopus-indexed article) 

Mandal, S. C., et al. (2003). Safety and pharmacological study of Ferula asafoetida. Journal of Ethnopharmacology, 86(3), 295-300.

Punica granatum (Dadima Fruit Rind / Pomegranate Peel) 

Safety & Tolerability Overview 

Pomegranate rind extracts demonstrate strong safety profiles in animal and human ingestion studies, with no adverse liver, kidney, or hematological effects and no toxicity at therapeutic intake levels. 

Peel extracts are considered safe, non-hormonal, and well tolerated when standardized. 

Clinical Risk Considerations 

• Culinary / nutraceutical doses well tolerated 

References (Scopus-indexed article) 

Johanningsmeier, S. D., & Harris, G. K. (2011). Review of safety and health properties of pomegranate. Comprehensive Reviews in Food Science and Food Safety, 10(4), 318-336.

Potassium Sorbate 

Safety & Tolerability Overview 

Potassium sorbate is a widely approved food-grade preservative used to inhibit microbial growth. Toxicology evaluations consistently demonstrate excellent safety at permitted dietary concentrations, with no evidence of carcinogenicity, mutagenicity, neurotoxicity, or endocrine disruption. 

It is rapidly metabolized and excreted via normal energy pathways. 

Clinical Risk Considerations 

• Approved globally as safe at regulated intake thresholds 

References (Scopus-indexed articles) 

Walker, R. (1990). Safety evaluation of sorbic acid and potassium sorbate. Food Additives & Contaminants, 7(5), 657-676. 

WHO/FAO Joint Expert Committee on Food Additives. (2000). Evaluation of certain food additives- potassium sorbate safety monograph.

Disodium EDTA 

Safety & Tolerability Overview 

Disodium EDTA is an internationally approved pharmaceutical and cosmetic excipient used primarily as a chelating and stabilizing agent. Toxicological reviews confirm minimal systemic absorption through the skin and gastrointestinal tract at permitted usage concentrations. 

Formal safety assessments report no reproductive toxicity, no carcinogenicity, and no endocrine-disrupting actions at regulated exposure levels. Local skin tolerability is rated as good, with extremely low irritancy potential. 

Clinical Risk Considerations 

• Safe across oral, topical, and parenteral approved contexts 

References (Scopus-indexed articles) 

CIR Expert Panel. (2002). Safety assessment of EDTA, calcium disodium EDTA, and related salts. International Journal of Toxicology, 21(2), 95-142.

Scientific Transparency Note

The information shared here reflects a carefully curated overview of the available scientific literature on commonly used botanical and food-grade ingredients. The references listed are illustrative, not exhaustive and are provided so that interested readers may understand the type and quality of research that exists in the public domain. 

As part of our ongoing commitment to informed product development, a very large volume of published scientific work including clinical studies, pharmacological research, toxicology assessments, and regulatory reviews is continuously reviewed and evaluated by our team before an ingredient is considered suitable for inclusion in a formulation. The intention in sharing selected references is not to claim exclusivity of evidence, nor to imply that outcomes from individual studies can be universally applied. 

Botanical science is diverse: differences in study design, dosage, extract type, population characteristics, and outcome measures mean that findings may not always be directly comparable or generalizable. For this reason, we encourage readers to approach scientific literature thoughtfully, seek professional guidance where appropriate, and review primary sources independently. 

This document is intended solely for general informational and educational purposes. It should not be interpreted as medical advice, health claims, or product-specific claims of prevention, diagnosis, treatment, cure, or guaranteed safety. Nothing stated here is intended to be misleading or to replace the advice of qualified healthcare professionals. 

Our goal in providing this information is simple: to support clarity, transparency, and scientific awareness, without overstatement, without sensationalism, and without encouraging self-diagnosis or over-generalization.