
Period Pain Isn’t Just “Cramps”, it’s also digestive pain caused by gut inflammation, bloating, gas, and acidity. Treating both is the only way to feel truly normal again.
Works inside AND outside your body
Cramp Relief Gel = Reduces cramps (Rhythmic pattern pain that comes and goes in waves pattern)
Debloat Superfood = Reduces internal digestive pain (Continuous period pain that stays with heaviness)
Together, they reduce your whole period pain quickly.
Helps you feel normal again, faster
By reducing both cramping pain and gut pressure, this combo helps
you go from:
“I can’t deal with this” → “I feel fine now”
in under 15 minutes.
Most women think period pain only comes from the uterus tightening. But the truth is: your gut suffers just as
much during your period, sometimes even more!
HOW THIS COMBO MATTERS
It relaxes muscles, reduces inflammation,
and calms the cramping sensation.
+
It reduces gut inflammation, acidity, bloating, gas, and water retention, the other half of period pain most women NOT aware of.
Summary of the studies conducted
| Study Name | Study Type / Model | Key Findings / Results | Conclusion / Outcome |
|---|---|---|---|
| 1. Skin Irritation Study | In-vivo (6 male Wistar rats) | Draize scores: 0.0-0.5; no erythema, edema, or irritation observed; normal histopathology | Non-irritant and well-tolerated upon repeated dermal exposure |
| 2. Carrageenan-Induced Paw Edema Study | In-vivo anti-inflammatory model (18 Wistar rats) | Significant reduction in paw edema vs control; inhibition comparable to NSAID reference drug | Confirms strong anti-inflammatory and prostaglandin-suppressing activity |
| 3. Acute Oral Toxicity Study | In-vivo (15 albino rats) | No mortality or systemic toxicity; normal histopathology and stable body weight | Safe at high oral doses; LD₅₀ exceeds tested limits |
| 4. Experimental Dysmenorrhea Rat Model | In-vivo (Oxytocin-induced uterine contraction model) | Significant reduction in writhing behavior and PGF₂α levels; superior to Mefatal-Spas | Demonstrated superior spasmolytic and prostaglandin-modulating action |
| 5. Human Pilot Study - Cramp Relief Gel & Debloat Superfood (n = 90) | Randomized controlled pilot (90 women, 3 cycles) | Onset of action within 10-30 sec; 90% achieved >80% pain reduction; no side effects | Significantly faster, safer, and more effective than NSAIDs and home remedies |
| 6. In-vitro Dissolution Study | Simulated vaginal fluid (SVF) | Rapid release within 1 min; sustained release up to 8 hrs; diffusion-controlled mechanism (R² ≈ 0.98) | Optimized biphasic release ensuring instant + long-lasting relief |
| 7. Vaginal Irritation Study | In-vivo (New Zealand white rabbits) | No erythema, edema, or abnormal discharge; normal histopathology | Classified as non-irritant to vaginal mucosa; highly biocompatible |
| 8. Cytotoxicity Study (L929 Fibroblasts) | In-vitro cell viability assay | >90% cell viability across all concentrations; normal morphology | Non-cytotoxic; safe for dermal and mucosal contact |
| 9. Skin Sensitization Study | In-vivo (Wistar rats, ISO 10993-10) | No erythema, edema, or lymphoid activation; histopathology normal | Non-sensitizing and safe for prolonged dermal use |
| 10. Therapeutic Efficacy in Dysmenorrhea Model | In-vivo (Rat model) | Reduced writhing, normalized uterine histology; PGF₂α ↓ to 35-40 ng/mL, PGE₂ undetectable, TNF-α < assay detection | Potent anti-dysmenorrheic efficacy; equal or greater than NSAIDs |
| 11. Anti-Inflammatory Evaluation (Carrageenan Model) | In-vivo (Rat model, ISO 10993-11) | 65.36% inhibition of inflammation at 6 h (NSAID: 118.79%); p < 0.01 | Strong topical anti-inflammatory action validating NSAID-like efficacy |
| 12. Human Observational Study- Sanitary Pad (n=30) | Prospective open-label, 3 menstrual cycles | Pain reduced from VAS 7.4 → 2.1 (p < 0.001); >70% reduction in bloating; 87% strong user preference; no AEs | Clinically effective, safe, and well-tolerated; improved comfort and function |
Summary of the studies conducted
| Study Name | Study Type / Model | Key Findings / Results | Conclusion / Outcome |
|---|---|---|---|
| 1. Skin Irritation Study | In-vivo (6 male Wistar rats) | Draize scores: 0.0-0.5; no erythema, edema, or irritation observed; normal histopathology | Non-irritant and well-tolerated upon repeated dermal exposure |
| 2. Carrageenan-Induced Paw Edema Study | In-vivo anti-inflammatory model (18 Wistar rats) | Significant reduction in paw edema vs control; inhibition comparable to NSAID reference drug | Confirms strong anti-inflammatory and prostaglandin-suppressing activity |
| 3. Acute Oral Toxicity Study | In-vivo (15 albino rats) | No mortality or systemic toxicity; normal histopathology and stable body weight | Safe at high oral doses; LD₅₀ exceeds tested limits |
| 4. Experimental Dysmenorrhea Rat Model | In-vivo (Oxytocin-induced uterine contraction model) | Significant reduction in writhing behavior and PGF₂α levels; superior to Mefatal-Spas | Demonstrated superior spasmolytic and prostaglandin-modulating action |
| 5. Human Pilot Study - Cramp Relief Gel & Debloat Superfood (n = 90) | Randomized controlled pilot (90 women, 3 cycles) | Onset of action within 10-30 sec; 90% achieved >80% pain reduction; no side effects | Significantly faster, safer, and more effective than NSAIDs and home remedies |
| 6. In-vitro Dissolution Study | Simulated vaginal fluid (SVF) | Rapid release within 1 min; sustained release up to 8 hrs; diffusion-controlled mechanism (R² ≈ 0.98) | Optimized biphasic release ensuring instant + long-lasting relief |
| 7. Vaginal Irritation Study | In-vivo (New Zealand white rabbits) | No erythema, edema, or abnormal discharge; normal histopathology | Classified as non-irritant to vaginal mucosa; highly biocompatible |
| 8. Cytotoxicity Study (L929 Fibroblasts) | In-vitro cell viability assay | >90% cell viability across all concentrations; normal morphology | Non-cytotoxic; safe for dermal and mucosal contact |
| 9. Skin Sensitization Study | In-vivo (Wistar rats, ISO 10993-10) | No erythema, edema, or lymphoid activation; histopathology normal | Non-sensitizing and safe for prolonged dermal use |
| 10. Therapeutic Efficacy in Dysmenorrhea Model | In-vivo (Rat model) | Reduced writhing, normalized uterine histology; PGF₂α ↓ to 35-40 ng/mL, PGE₂ undetectable, TNF-α < assay detection | Potent anti-dysmenorrheic efficacy; equal or greater than NSAIDs |
| 11. Anti-Inflammatory Evaluation (Carrageenan Model) | In-vivo (Rat model, ISO 10993-11) | 65.36% inhibition of inflammation at 6 h (NSAID: 118.79%); p < 0.01 | Strong topical anti-inflammatory action validating NSAID-like efficacy |
| 12. Human Observational Study- Sanitary Pad (n=30) | Prospective open-label, 3 menstrual cycles | Pain reduced from VAS 7.4 → 2.1 (p < 0.001); >70% reduction in bloating; 87% strong user preference; no AEs | Clinically effective, safe, and well-tolerated; improved comfort and function |
WHY WOMEN PREFER...